Publications

2016

Miller, R. M., Zhang, X., Maxwell, A., Cain, C., & Xu, Z. (2016). Bubble-induced Color Doppler Feedback for Histotripsy Tissue Fractionation (DRAFT), 3010(c). http://doi.org/10.1109/TUFFC.2016.2525859

2015

Devanagondi, R., Zhang, X., Xu, Z., Ives, K., Levin, A., Gurm, H., & Owens, G. E. (2015). Hemodynamic and Hematologic Effects of Histotripsy of Free-Flowing Blood: Implications for Ultrasound-Mediated Thrombolysis. Journal of Vascular and Interventional Radiology, 26(10), 1559–1565. http://doi.org/10.1016/j.jvir.2015.03.022

Khokhlova, V. A., Fowlkes, J. B., Roberts, W. W., Schade, G. R., Xu, Z., Khokhlova, T. D., … Cain, C. A. (2015). Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications. Int J Hyperthermia, 31(2), 1464–5157. http://doi.org/10.3109/02656736.2015.1007538

Miller, R. M., Zhang, X., Maxwell, A. D., Wang, T. Y., Brian Fowlkes, J., Cain, C. A., & Xu, Z. (2015). Investigation of the mechanism of ARFI-based Color Doppler feedback of histotripsy tissue fractionation. IEEE International Ultrasonics Symposium, IUS, 934–937. http://doi.org/10.1109/ULTSYM.2013.0240

Vlaisavljevich, E., Lin, K.-W., Maxwell, A., Warnez, M. T., Mancia, L., Singh, R., … Xu, Z. (2015). Effects of Ultrasound Frequency and Tissue Stiffness on the Histotripsy Intrinsic Threshold for Cavitation. Ultrasound in Medicine & Biology, 41(6), 1651–1667. http://doi.org/10.1016/j.ultrasmedbio.2015.01.028

Vlaisavljevich, E., Lin, K.-W., Warnez, M. T., Singh, R., Mancia, L., Putnam, A. J., … Xu, Z. (2015). Effects of tissue stiffness, ultrasound frequency, and pressure on histotripsy-induced cavitation bubble behavior. Physics in Medicine and Biology, 60(6), 2271–2292. http://doi.org/10.1088/0031-9155/60/6/2271

Zhang, X., Miller, R. M., Lin, K. W., Levin, A. M., Owens, G. E., Gurm, H. S., … Xu, Z. (2015). Real-time feedback of histotripsy thrombolysis using bubble-induced color doppler. Ultrasound in Medicine and Biology, 41(5), 1386–1401. http://doi.org/10.1016/j.ultrasmedbio.2014.12.006

Zhang, X., Owens, G. E., Gurm, H. S., Ding, Y., Cain, C. A., Arbor, A., … Arbor, A. (2015). Non-invasive Thrombolysis using Histotripsy beyond the “Intrinsic” Threshold (Microtripsy). IEEE Trans Ultrason Ferroelectr Freq Control, 62(734), 1342–1355. http://doi.org/10.1109/TUFFC.2015.007016.Non-invasive

2014

Kim, Y., Hall, T., Xu, Z., & Cain, C. (2014). Transcranial histotripsy therapy: A feasibility study. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 61(4), 582–593. http://doi.org/10.1109/TUFFC.2014.2947

Kim, Y., Maxwell, A. D., Hall, T. L., Xu, Z., Lin, K.-W., & Cain, C. (2014). Rapid Prototyping Fabrication of Focused Ultrasound Transducers. IEEE Transactions on Ultrasonics, 61(9), 303–353. http://doi.org/10.1002/0471221155

Kim, Y., Vlaisavljevich, E., Owens, G. E., Allen, S. P., Cain, C. a, & Xu, Z. (2014). In vivo transcostal histotripsy therapy without aberration correction. Physics in Medicine and Biology, 59(11), 2553–2568. http://doi.org/10.1088/0031-9155/59/11/2553

Lin, K., Duryea, A. P., Kim, Y., Hall, T. L., Xu, Z., & Cain, C. A. (2014). Dual-Beam Histotripsy : A Low-Frequency Pump Enabling a High-Frequency Probe for Precise Lesion Formation, 61(2).

Lin, K. W., Hall, T. L., Xu, Z., & Cain, C. A. (2014). Histotripsy Lesion Formation Using an Ultrasound Imaging Probe Enabled by a Low-Frequency Pump Transducer. Ultrasound in Medicine and Biology, 41(8), 2148–2160. http://doi.org/10.1016/j.ultrasmedbio.2015.03.026

Lin, K. W., Hall, T., McGough, R., Xu, Z., & Cain, C. (2014). Synthesis of monopolar ultrasound pulses for therapy: The frequency-compounding transducer. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 61(7), 1123–1136. http://doi.org/10.1109/TUFFC.2014.3012

Lin, K. W., Kim, Y., Maxwell, A., Wang, T. Y., Hall, T., Xu, Z., … Cain, C. (2014). Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: Microtripsy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 61(2), 251–265. http://doi.org/10.1109/TUFFC.2014.6722611

Maxwell, A. D., Park, S., Vaughan, B. L., Cain, C. a, Grotberg, J. B., & Xu, Z. (2014). Trapping of embolic particles in a vessel phantom by cavitation-enhanced acoustic streaming. Physics in Medicine and Biology, 59(17), 4927–43. http://doi.org/10.1088/0031-9155/59/17/4927

Vlaisavljevich, E., Kim, Y., Owens, G., Roberts, W., Cain, C., & Xu, Z. (2014). Effects of tissue mechanical properties on susceptibility to histotripsy-induced tissue damage. Physics in Medicine and Biology, 59(2), 253–70. http://doi.org/10.1088/0031-9155/59/2/253

Vlaisavljevich, E., Maxwell, A., Warnez, M., Johnsen, E., Cain, C. a, & Xu, Z. (2014). Histotripsy-Induced Cavitation Cloud Mechanical Properties. IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 61(2), 341–352.

Wang, T. Y., Hall, T., Xu, Z., Fowlkes, J., & Cain, C. (2014). Imaging feedback for histotripsy by characterizing dynamics of acoustic radiation force impulse (arfi)-induced shear waves excited in a treated volume. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 61(7), 1137–1151. http://doi.org/10.1109/TUFFC.2014.3013

Yuksel Durmaz, Y., Vlaisavljevich, E., Xu, Z., & Elsayed, M. (2014). Development of nanodroplets for histotripsy-mediated cell ablation. Molecular Pharmaceutics, 11(10), 3684–3695. http://doi.org/10.1021/mp500419w

2013

Allam, C. L., Wilkinson, J. E., Cheng, X., Ives, K. a., Hall, T. L., & Roberts, W. W. (2013). Histotripsy Effects on the Bladder Trigone: Functional and Histologic Consequences in the Canine Model. Journal of Endourology, 27(10), 1267–1271. http://doi.org/10.1089/end.2013.0234

Keller, J. M., Schade, G. R., Ives, K., Cheng, X., Rosol, T. J., Piert, M., … Keller, E. T. (2013). A novel canine model for prostate cancer. Prostate, 73(9), 952–959. http://doi.org/10.1002/pros.22642

Kim, Y., Fifer, C. G., Gelehrter, S. K., Owens, G. E., Berman, D. R., Vlaisavljevich, E., … Xu, Z. (2013). Developmental Impact and Lesion Maturation of Histotripsy-Mediated Non-Invasive Tissue Ablation in a Fetal Sheep Model. Ultrasound in Medicine and Biology, 39(6), 1047–1055. http://doi.org/10.1016/j.ultrasmedbio.2012.12.014

Maxwell, A. D., Cain, C. a., Hall, T. L., Fowlkes, J. B., & Xu, Z. (2013). Probability of Cavitation for Single Ultrasound Pulses Applied to Tissues and Tissue-Mimicking Materials. Ultrasound in Medicine and Biology, 39(3), 449–465. http://doi.org/10.1016/j.ultrasmedbio.2012.09.004

Miller, R. M., Kim, Y., Lin, K. W., Cain, C. a., Owens, G. E., & Xu, Z. (2013). Histotripsy Cardiac Therapy System Integrated with Real-Time Motion Correction. Ultrasound in Medicine and Biology, 39(12), 2362–2373. http://doi.org/10.1016/j.ultrasmedbio.2013.08.004

Park, S., Maxwell, A. D., Owens, G. E., Gurm, H. S., Cain, C. a., & Xu, Z. (2013). Non-Invasive Embolus Trap Using Histotripsy-An Acoustic Parameter Study. Ultrasound in Medicine and Biology, 39(4), 611–619. http://doi.org/10.1016/j.ultrasmedbio.2012.11.026

Vlaisavljevich, E., Durmaz, Y. Y., Maxwell, A., ElSayed, M., & Xu, Z. (2013). Nanodroplet-mediated histotripsy for image-guided targeted ultrasound cell ablation. Theranostics, 3(11), 851–864. http://doi.org/10.7150/thno.6717

Vlaisavljevich, E., Kim, Y., Allen, S., Owens, G., Pelletier, S., Cain, C., … Xu, Z. (2013). Image-Guided Non-Invasive Ultrasound Liver Ablation Using Histotripsy: Feasibility Study in an In Vivo Porcine Model. Ultrasound in Medicine & Biology, 39(8), 1398–1409. http://doi.org/10.1016/j.ultrasmedbio.2013.02.005

2012

Baac, H. W., Ok, J. G., Maxwell, A., Lee, K.-T., Chen, Y.-C., Hart,  a J., … Guo, L. J. (2012). Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy. Scientific Reports, 2, 989. http://doi.org/10.1038/srep00989

Maxwell, A., Xu, Z., & Gurm, H. (2012). Feasibility of Noninvasive Atherectomy: Plaque Ablation with Cavitation-Based Focused Ultrasound (Histotripsy). Journal of the American College of Cardiology, 60(17), B35. http://doi.org/10.1016/j.jacc.2012.08.131

Owens, G. E., Miller, R. M., Owens, S. T., Swanson, S. D., Ives, K., Ensing, G., … Xu, Z. (2012). Intermediate-term effects of intracardiac communications created noninvasively by therapeutic ultrasound (histotripsy) in a porcine model. Pediatric Cardiology, 33(1), 83–89. http://doi.org/10.1007/s00246-011-0094-6

Schade, G. R., Keller, J., Ives, K., Cheng, X., Rosol, T. J., Keller, E., & Roberts, W. W. (2012). Histotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model. Journal of Urology, 188(5), 1957–1964. http://doi.org/10.1016/j.juro.2012.07.006

Wang, T. Y., Hall, T. L., Xu, Z., Fowlkes, J. B., & Cain, C. a. (2012). Imaging feedback of histotripsy treatments using ultrasound shear wave elastography. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 59(6), 1167–1181. http://doi.org/10.1109/TUFFC.2012.2307

Wang, T.-Y., Xu, Z., Hall, T. L., Fowlkes, J. B., & Cain, C. a. (2012). An Efficient Treatment Strategy for Histotripsy by Removing Cavitation Memory. Ultrasound in Medicine & Biology, 38(5), 753–766. http://doi.org/10.1016/j.ultrasmedbio.2012.01.013

2011

Duryea, A. P., Hall, T. L., Maxwell, A. D., Xu, Z., Cain, C. a, & Roberts, W. W. (2011). Histotripsy erosion of model urinary calculi. Journal of Endourology / Endourological Society, 25(2), 341–344. http://doi.org/10.1089/end.2010.0407

Duryea, A. P., Maxwell, A. D., Roberts, W. W., Xu, Z., Hall, T. L., & Cain, C. a. (2011). In vitro comminution of model renal calculi using histotripsy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 58(5), 971–980. http://doi.org/10.1109/TUFFC.2011.1898

Hempel, C. R., Hall, T. L., Cain, C. a., Fowlkes, J. B., Xu, Z., & Roberts, W. W. (2011). Histotripsy fractionation of prostate tissue: Local effects and systemic response in a canine model. Journal of Urology, 185(4), 1484–1489. http://doi.org/10.1016/j.juro.2010.11.044

Kim, Y., Gelehrter, S. K., Fifer, C. G., Lu, J. C., Owens, G. E., Berman, D. R., … Xu, Z. (2011). Non-invasive pulsed cavitational ultrasound for fetal tissue ablation: Feasibility study in a fetal sheep model. Ultrasound in Obstetrics and Gynecology, 37(4), 450–457. http://doi.org/10.1002/uog.8880

Kim, Y., Wang, T., Xu, Z., & Cain, C. a. (2011). Lesion Generation Through Ribs Using Histotripsy Therapy Without Aberration Correction, 58(11), 2334–2343.

Maxwell, A. D., Owens, G., Gurm, H. S., Ives, K., Myers, D. D., & Xu, Z. (2011). Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model. Journal of Vascular and Interventional Radiology, 22(3), 369–377. http://doi.org/10.1016/j.jvir.2010.10.007

Maxwell, A. D., Wang, T.-Y., Cain, C. a., Fowlkes, J. B., Sapozhnikov, O. a., Bailey, M. R., & Xu, Z. (2011). Cavitation clouds created by shock scattering from bubbles during histotripsy. The Journal of the Acoustical Society of America, 130(4), 1888. http://doi.org/10.1121/1.3625239

Owens, G. E., Miller, R. M., Ensing, G., Ives, K., Gordon, D., Ludomirsky, A., & Xu, Z. (2011). Therapeutic ultrasound to noninvasively create intracardiac communications in an intact animal model. Catheterization and Cardiovascular Interventions, 77(4), 580–588. http://doi.org/10.1002/ccd.22787

Wang, T. Y., Xu, Z., Hall, T. L., Fowlkes, J. B., Roberts, W. W., & Cain, C. a. (2011). Active focal zone sharpening for high-precision treatment using histotripsy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 58(2), 305–315. http://doi.org/10.1109/TUFFC.2011.1808

Winterroth, F., Xu, Z., Wang, T. Y., Wilkinson, J. E., Fowlkes, J. B., Roberts, W. W., & Cain, C. a. (2011). Examining and analyzing subcellular morphology of renal tissue treated by histotripsy. Ultrasound in Medicine and Biology, 37(1), 78–86. http://doi.org/10.1016/j.ultrasmedbio.2010.10.002

2010

Maxwell, A. D., Owens, G., Gurm, H. S., Ives, K., Myers, D. D., & Xu, Z. (2011). Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model. Journal of Vascular and Interventional Radiology, 22(3), 369–377. http://doi.org/10.1016/j.jvir.2010.10.007

Maxwell, A. D., Wang, T. Y., Yuan, L., Duryea, A. P., Xu, Z., & Cain, C. a. (2010). A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage. Ultrasound in Medicine and Biology, 36(12), 2132–2143. http://doi.org/10.1016/j.ultrasmedbio.2010.08.023

Wheat, J. C., Hall, T. L., Hempel, C. R., Cain, C. a., Xu, Z., & Roberts, W. W. (2010). Prostate Histotripsy in an Anticoagulated Model. Urology, 75(1), 207–211. http://doi.org/10.1016/j.urology.2009.09.021

Xu, Z., Owens, G., Gordon, D., Cain, C., & Ludomirsky, A. (2010). Noninvasive creation of an atrial septal defect by histotripsy in a canine model. Circulation, 121(6), 742–749. http://doi.org/10.1161/CIRCULATIONAHA.109.889071

Prior to 2010

Hall, T. L., Hempel, C. R., Wojno, K., Xu, Z., Cain, C. a., & Roberts, W. W. (2009). Histotripsy of the Prostate: Dose Effects in a Chronic Canine Model. Urology, 74(4), 932–937. http://doi.org/10.1016/j.urology.2009.03.049

Lake,  a. M., Xu, Z., Wilkinson, J. E., Cain, C. a., & Roberts, W. W. (2008). Renal Ablation by Histotripsy-Does it Spare the Collecting System? Journal of Urology, 179(3), 1150–1154. http://doi.org/10.1016/j.juro.2007.10.033

Maxwell, A. D., Cain, C. a., Duryea, A. P., Yuan, L., Gurm, H. S., & Xu, Z. (2009). Noninvasive Thrombolysis Using Pulsed Ultrasound Cavitation Therapy – Histotripsy. Ultrasound in Medicine and Biology, 35(12), 1982–1994. http://doi.org/10.1016/j.ultrasmedbio.2009.07.001

Wang, T., Xu, Z., Winterroth, F., Hall, T. L., Fowlkes, J. B., Rothman, E. D., … Cain, C. a. (2009). Quantitative ultrasound backscatter for  pulsed cavitational ultrasound therapy-  histotripsy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 56(5), 995–1005. http://doi.org/10.1109/TUFFC.2009.1131

Xu, Z., Fan, Z., Hall, T. L., Winterroth, F., Fowlkes, J. B., & Cain, C. a. (2009). Size Measurement of Tissue Debris Particles Generated from Pulsed Ultrasound Cavitational Therapy – Histotripsy. Ultrasound in Medicine and Biology, 35(2), 245–255. http://doi.org/10.1016/j.ultrasmedbio.2008.09.002

Xu, Z., Fowlkes, J. B., & Cain, C. a. (2006). A new strategy to enhance cavitational tissue erosion using a high-intensity, initiating sequence. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 53(8), 1412–1424. http://doi.org/10.1109/TUFFC.2006.1665098

Xu, Z., Fowlkes, J. B., Ludomirsky, A., & Cain, C. a. (2005). Investigation of intensity thresholds for ultrasound tissue erosion. Ultrasound in Medicine and Biology, 31(12), 1673–1682. http://doi.org/10.1016/j.ultrasmedbio.2005.07.016

Xu, Z., Fowlkes, J. B., Rothman, E. D., Levin, A. M., & Cain, C. a. (2005). Controlled ultrasound tissue erosion: the role of dynamic interaction between insonation and microbubble activity. The Journal of the Acoustical Society of America, 117(1), 424–435. http://doi.org/10.1121/1.1828551

Xu, Z., Hall, T. L., Fowlkes, J. B., & Cain, C. a. (2007a). Effects of acoustic parameters on bubble cloud dynamics in ultrasound tissue erosion (histotripsy). The Journal of the Acoustical Society of America, 122(1), 229–236. http://doi.org/10.1121/1.2735110

Xu, Z., Hall, T. L., Fowlkes, J. B., & Cain, C. a. (2007b). Optical and acoustic monitoring of bubble dynamics at a tissue-fluid interface in ultrasound tissue erosion. AIP Conference Proceedings, 829(April), 343–347. http://doi.org/10.1063/1.2205494

Xu, Z., Ludomirsky, A., Eun, L. Y., Hall, T. L., Tran, B. C., Fowlkes, J. B., & Cain, C. a. (2004). Controlled ultrasound tissue erosion. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 51(6), 726–736. http://doi.org/10.1109/TUFFC.2004.1304271

Xu, Z., Raghavan, M., Hall, T. L., Chang, C. W., Mycek, M. A., Fowlkes, J. B., & Cain, C. a. (2006). High speed imaging of bubble clouds in pulsed cavitational ultrasound therapy – Histotripsy. Proceedings – IEEE Ultrasonics Symposium, 1(10), 293–296. http://doi.org/10.1109/ULTSYM.2006.86

Xu, Z., Raghavan, M., Hall, T. L., Mycek, M., & Fowlkes, J. B. (2008). Evolution of bubble clouds induced by pulsed cavitational ultrasound therapy – histotripsy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 55(5), 1122–1132. http://doi.org/10.1109/TUFFC.2008.764